Projects
Tomorrow's treatments today:
Specific targeting of tumour cells - In the laboratory we have developed a protein called a single chain antibody for the treatment of cancer. The protein has been engineered to recognise a specific biomarker found only on the surface of tumour cells and a system has been developed to produce this protein at low cost and high quality, and is now attaching radioactive isotopes. The ultimate aim is delivering a toxic dose of radiation to tumour cells while leaving non-tumour cells intact, thus providing a more targeted approach to treating specific cancers.
Monitoring the effect of cancer and cancer treatment on male fertility: towards a diagnostic test -
The purpose of this study will be to develop "genomic sperm screening technology" aimed at improving the welfare of patients who are recovering from, and under treatment for, Hodgkin's Lymphoma and testicular cancer. We aim, ultimately, to provide information about the most suitable period of time from which such patients can think of starting or extending their family. In so doing, we hope to provide insight into the origins of gross genetic alterations in the sperm of cancer patients before, during and after chemotherapy.
Nano Medicine: Killing cancer cells from within -
Oligonucleotides are new drugs with potential to treat patients with diseases such as cancer, cardiovascular and infectious diseases. An advantage for the patients compared to traditional treatments may be reduced side effects. However, efficient delivery of oligonucleotides to diseased cells remains an issue. We propose to use polymers to carry the drug inside cancerous cells and kill them from within.
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